Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề tách rời

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000002380.pdf.jpg
  • Journal Article

  • Dysregulated DnaB unwinding induces replisome decoupling and daughter strand gaps that are countered by RecA polymerization

    • Tác giả : Behrmann, Megan S. (2023)

  • Repair of DNA damage begins with the elicitation of targeted cellular responses to restore the 20 genome. In E. coli, major products of DNA damage result in the buildup of single-stranded DNA 21 (ssDNA) that is rapidly bound by cooperative filamentation of RecA to initiate the SOS 22 response. The replicative helicase, DnaB, is a central component of the replisome, unwinding 23 duplex DNA in concert with Pol III template dependent syn...
  • OER000002977.pdf.jpg
  • Journal article

  • Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

    • Tác giả : Kolata, Piotr (2021)

  • Respiratory complex I is a multi-subunit membrane protein complex that reversibly couples NADH oxidation and ubiquinone reduction with proton translocation against trans-membrane potential. Complex I from Escherichia coli is among the best functionally characterizedcomplexes, but its structure remains unknown, hindering further mechanistic studies to understand the enzyme coupling mechanism. Here we describe the single particle cryo electron microscopy (cryo-EM) structure of th...