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  • OER000002750.pdf.jpg
  • Journal article

  • Conditional covalent lethality driven by oncometabolite accumulation

    • Authors : Perez, Minervo (2023)

  • Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a cancer predisposition syndrome driven by mutation of the tumor suppressor fumarate hydratase (FH). Inactivation of FH causes accumulation of the electrophilic oncometabolite fumarate. In the absence of methods for reactivation, tumor suppressors can be targeted via identification of synthetic lethal interactions using genetic screens. Inspired by recent advances in chemoproteomic target identific...
  • OER000002598.pdf.jpg
  • Journal article

  • Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

    • Authors : Choi, Yong Mi (2023)

  • Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of 36 triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins 37 called perilipins (PLINs). During LD biogenesis, perilipin 3 (PLIN3) is recruited to nascent LDs as 38 they emerge from the endoplasmic reticulum. Here, we analyzed how lipid composition affects 39 PLIN3 recruitment to membrane bilayers and LDs, and t...