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Journal article

Distinct phosphorylation signals drive acceptor versus self-ubiquitination selection by Parkin

Authors : Dunkerley, Karen M. (2021)

The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative stress where it becomes activated and ubiquitinates numerous proteins. Parkin activation involves bind ing of a phosphorylated ubiquitin (pUb), followed by phosphorylation of parkin itself, both mediated by the OMM kinase, PINK1. However, targeted mitochon drial proteins have little structural or sequence sim ilarity, with the commonality between su...

Journal article

Influence of the TorD signal peptide chaperone on Tat-dependent protein translocation

Authors : Bageshwar, Umesh K. (2021)

The twin-arginine translocation (Tat) pathway transports folded proteins across energetic membranes. Numerous Tat substrates contain co-factors that are inserted before transport with the assistance of redox enzyme maturation proteins (REMPs), which bind to the signal peptide of precursor proteins. How signal peptides are transferred from a REMP to a binding site on the Tat receptor complex remains unknown. Since the signal peptide mediates both ...

Journal article

Linking medicinal cannabis to autotaxin-lysophosphatic acid signaling

Authors : Eymery, Mathias C. (2023)

Autotaxin is primarily known for the formation of lysophosphatidic acid (LPA) from 22 lysophosphatidylcholine (LPC). LPA is an important signaling phospholipid that can bind to six 23 G-protein coupled receptors (LPA1-6). The ATX-LPA signaling axis is a critical component in 24 many physiological and pathophysiological conditions. Here, we describe a potent inhibition 25 of Δ9-trans-tetrahydrocannabinol (THC), the main psychoactive compound of medicinal &...