Browse

Author Profile

Browsing by Subject tín hiệu tế bào

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 3 of 3
  • OER000002281.pdf.jpg
  • Journal Article

  • Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γsecretase impairing downstream cell signaling

    • Authors : Orsburn, Benjamin C. (2023)

  • A recent study demonstrated a substantial signal increase when employing a 0.5% acetic acid buffer additive instead of the traditional 0.1% formic acid used in shotgun proteomics. In this study I compare these two buffers for a dilution series of tryptic digests down to 20 picograms peptide on column on a TIMSTOF single cell proteome (SCP) system. I observe a comparable relative level of signal increase as previously reported...
  • OER000002339.pdf.jpg
  • Journal Article

  • Distinct phases of cellular signaling revealed by time-resolved protein synthesis

    • Authors : Muir, Tom W. (2023)

  • The post-translational regulation of protein function is involved in most cellular processes. As such, synthetic biology tools that operate at this level provide opportunities for manipulating cellular states. Here, we deploy a proximity-triggered protein trans-splicing technology to enable the time-resolved synthesis of target proteins from pre-made parts. The modularity of the strategy allows for the addition or removal of various control elements as&#x...