Ebooks (Sách điện tử)Authors : Schubert, Katharina (2023)
Nonstructural protein 1 (Nsp1) produced by coronaviruses shuts down host protein synthesis in infected
cells. The C-terminal domain of SARS-CoV-2 Nsp1 was shown to bind to the small ribosomal subunit
to inhibit translation, but it is not clear whether this mechanism is broadly used by coronaviruses,
whether the N-terminal domain of Nsp1 binds the ribosome, or how Nsp1 specifically permits translation
of viral mRNAs. Here, we investigat... 
