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Showing results 1 to 7 of 7
  • OER000002456.pdf.jpg
  • Journal Article

  • Identification of the bacteriophage nucleus protein interaction network

    • Authors : Enustun, Eray (2023)

  • In the arms race between bacteria and bacteriophages (phages), some large-genome jumbo phages have evolved a protein shell that encloses their replicating genome to protect it against DNA-targeting immune factors. By segregating the genome from the host cytoplasm, however, the “phage nucleus” introduces the need to specifically transport mRNA and proteins through the nuclear shell, and to dock capsids on the shell for genome packaging. �...
  • OER000002485.pdf.jpg
  • Journal Article

  • Interplay of macromolecular interactions during assembly of human DNA polymerase δ holoenzymes and initiation of DNA synthesis

    • Authors : Norris, Jessica L.  (2023)

  • In humans, DNA polymerase δ (Pol δ) holoenzymes, comprised of Pol δ and the processivity sliding clamp, proliferating cell nuclear antigen (PCNA), carry out DNA synthesis during lagging strand DNA replication, initiation of leading strand DNA replication, and the major DNA damage repair and tolerance pathways. Pol δ holoenzymes are assembled at primer/template (P/T) junctions and initiate DNA synthesis in a coordinated process involving the major si...
  • OER000002404.pdf.jpg
  • Journal Article

  • Structural assembly of the bacterial essential interactome

    • Authors : Borrego, Jordi Gómez (2023)

  • The study of protein interactions in living organisms is fundamental to understanding biological processes and central metabolic pathways. However, our understanding of the bacterial interactome remains limited, hindering the identification of new drug targets and the development of new therapeutic strategies. Here, we predict the assembly of the essential proteins in bacteria using the deep learning protein folding algorithm Alphafold2. We modeled 1089 interactions be...
  • OER000002967.pdf.jpg
  • Journal article

  • The P1 and P2 helices of the Guanidinium-II riboswitch interact in a ligand-dependent manner

    • Authors : Fuks, Christin (2021)

  • Riboswitch RNAs regulate gene expression by conformational changes induced by environmental conditions and specific ligand binding. The guanidine-II riboswitch is proposed to bind the small molecule guanidinium and to subsequently form a kissing loop interaction between the P1 and P2 hairpins. While an interaction was shown for isolated hairpins in crystallization and EPR experiments, an intrastrand kissing loop formation has not been demonstrated. Here, we report...
  • OER000002496.pdf.jpg
  • Journal Article

  • Vibrio cholerae’s ToxRS Bile Sensing System

    • Authors : Gubensäk, N.  (2023)

  • Cholera represents a diarrheal disease caused by the Gram-negative bacterium Vibrio cholerae. Its environmental persistence causing recurring sudden outbreaks is enabled by V. cholerae’s rapid adaption to changing environments involving sensory proteins like ToxR and ToxS. Located at the inner membrane, ToxR and ToxS react to environmental stimuli like bile acid, thereby inducing survival strategies e.g. bile resistance and virulence regulation. Currently, transcript...
  • OER000001272.pdf.jpg
  • Book

  • Virtual Reality and Its Application in Education

    • Authors : Cvetković, Dragan (2021)

  • The introductory chapter presents the definitions and principles of VR, potential applications of VR and Augmented Reality (AR), and describes devices for VR. Chapter 2 clarifies the relationship between the body and the tangible or visible form of an idea, quality or feeling, in AR and VR, and the implications of essential- ism, for the virtual sublime. Chapter 3 synthesizes recent studies into a set of educational design principles for&...