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Journal article

High resolution studies of DNA lesion bypass by human DNA polymerase δ holoenzymes

Authors : Dannenberg, Rachel L. (2023)

During DNA replication, DNA lesions present in lagging strand templates are initially encountered by DNA polymerase  (pol ). The historical view for what transpires from these encounters is that replication of the afflicted lagging strand template abruptly stops, activating DNA damage tolerance (DDT) pathways that replicate the offending lesion and adjacent DNA sequence, allowing pol  to resume downstream. However, qualitative studies observed that human p...

Journal article

Inhibiting succinate release worsens cardiac reperfusion injury by enhancing mitochondrial reactive oxygen species generation

Authors : Milliken, Alexander S. (2023)

The metabolite succinate accumulates during cardiac ischemia. Within 5 min. of 22 reperfusion, succinate returns to baseline levels via both its release from cells and oxidation by 23 mitochondrial complex II (Cx-II). The latter drives reactive oxygen species (ROS) generation and 24 subsequent opening of the mitochondrial permeability transition (PT) pore, leading to cell death. 25 Targeting succinate dynamics (accumulation/oxidation/release) may be therapeutically...