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Showing results 1 to 4 of 4

Journal Article

Factors influencing the detergent-free membrane protein isolation using synthetic nanodisc-forming polymers

Authors : Krishnarjuna, Bankala (2023)

The detergent-free isolation of membrane proteins using synthetic polymers is becoming the desired approach for functional and structural studies of membrane proteins. Since the expression levels for many membrane proteins are low and a high yield of functionalized reconstituted membrane proteins is essential for in vitro studies, it is crucial to optimize the experimental conditions for a given polymer to effectively solubilize target membranes/...

Journal article

Novel exported bifunctional fusion enzymes with chorismate mutase and cyclohexadienyl dehydratase activity: shikimate pathway enzymes teamed up in no man’s land

Authors : Stocker, Christian (2023)

Chorismate mutase (CM) and cyclohexadienyl dehydratase (CDT) catalyze two subsequent reactions in the intracellular biosynthesis of phenylalanine. Surprisingly, exported CMs and CDTs exist in bacterial pathogens. Here, we report the discovery of novel and extremely rare exported bifunctional fusion enzymes, consisting of fused CM and CDT domains. Such enzymes were found in only nine bacterial species belonging to nonpathogenic γ- or β-proteobacteria....

Journal article

Tau protein aggregation associated with SARS-CoV-2 main protease

Authors : Eberle, Raphael Josef (2023)

The primary function of virus proteases is the proteolytic processing of the viral polyprotein. These 16 enzymes can also cleave host cell proteins, which is important for viral pathogenicity, modulation of 17 cellular processes, viral replication, the defeat of antiviral responses and modulation of the immune 18 response. It is known that COVID-19 can influence multiple tissues or organs and that infection can 19 damage the functionality of the...

Journal article

The C9Orf72 hexanucleotide repeat expansion aggregates by means of multimolecular G-quadruplex formation

Authors : Raguseo, Federica (2023)

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two neurodegenerative diseases genetically characterised by the expansion of the hexanucleotide repeat (GGGGCC)n. Here we investigated the formation of nucleic-acid secondary structures in the expansion repeats, and their role in generating aggregates that are characteristic of ALS/FDT. We observed significant aggregation of DNA (GGGGCC)n, which we ascribe to the formation of multimolecular G-quadruplexes&...