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  • OER000000924.pdf.jpg
  • Journal article

  • Production and Purification of Endogenously Modified tRNA-Derived Small RNAs

    • Authors : Drino, Aleksej; Oberbauer, Vera; Troger, Conor (2020)

  • During particular stress conditions, transfer RNAs (tRNAs) become substrates of stress-induced endonucleases, resulting in the production of distinct tRNA-derived small RNAs (tsRNAs). These small RNAs have been implicated in a wide range of biological processes, but how isoacceptor and even isodecoder-specific tsRNAs act at the molecular level is still poorly understood. Importantly, stress-induced tRNA cleavage affects only a few tRNAs of a given isoacceptor or i...
  • OER000002658.pdf.jpg
  • Journal article

  • Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches

    • Authors : Nguyen, Ha An (2023)

  • Rapid and accurate translation is essential in all organisms to produce properly folded and functional proteins. mRNA codons that define the protein coding sequences are decoded by tRNAs on the ribosome in the aminoacyl (A) binding site. The mRNA codon and the tRNA anticodon interaction is extensively monitored by the ribosome to ensure accuracy in tRNA selection. While other polymerases that synthesize DNA and RNA can correct for...