Journal articleAuthors : Kustusz, Agata Gluszek (2023)
During mitosis, spindle architecture alters as chromosomes segregate to daughter cells. The
microtubule crosslinker Protein Required for Cytokinesis 1 (PRC1) is essential for spindle
stability, chromosome segregation and completion of cytokinesis, but how it recruits motors to
the central spindle to coordinate the segregation of chromosomes is unknown. Here, we
combine structural and cell biology approaches to show that the human CENP-E motor, which&...