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Journal article

Evolutionary adaptation of the folding pathway for secretability

Authors : Smets, Dries (2023)

Secretory preproteins of the Sec pathway bear signal peptides and are targeted 34 post-translationally to cross the plasma membrane or ER through 35 translocases. After translocation and signal peptide cleavage, mature domains 36 fold to native states in the bacterial periplasm or after further trafficking. 37 During cytoplasmic transit, mature domains must remain non-folded for 38 translocase recognition and translocation. Here, we sought the structural basis...

Journal Article

Evolutionary spread of protein L-(iso)aspartyl O-methyltransferases guides the discovery of distinct isoaspartate-containing peptides, pimtides

Authors : Lee, Hyunbin (2023)

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a structurally diverse class of natural products with a distinct biosynthetic logic, the enzymatic modification of genetically encoded precursor peptides. Although their structural and biosynthetic diversity remains largely underexplored, the identification of novel subclasses with unique structural motifs and biosynthetic pathways has been challenging. Here, we report that protein L-(iso)aspartyl O-methyltransferases&#x...

Ebooks (Sách điện tử)

The folding-limited nucleation of curli hints at an evolved safety mechanism for functional amyloid production

Authors : Claridge, Jolyon K. (2023)

It is nearly two decades ago that the ‘thin aggregative fimbriae’ which had been shown to enhance the biofilm formation of Salmonella enteriditis and Escherichia coli were identified as amyloid fibers. The realization that natural proteins can develop amyloidogenic traits as part of their functional repertoire instigated a search for similar proteins across all kingdoms of life. That pursuit has since unearthed dozens of candidates which&#x...