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  • OER000002311.pdf.jpg
  • Journal Article

  • Nucleotide-protocell interactions: A reciprocal relationship in prebiotically pertinent environments

    • Authors : deshpande, kshitij (2023)

  • Compartmentalization is a primary attribute of cellular life, and hence, the emergence of compartments is considered a central step in the emergence of the earliest protocells.[1–3] Life is thought to have originated in chemically heterogeneous environments, where different chemical entities would have spontaneously interacted with each other, affecting each other’s properties.[4,5] Fatty acids and nucleotides are found abundantly in extant life and are also considered...
  • OER000002638.pdf.jpg
  • Journal article

  • RNA-catalyzed RNA Ligation within Prebiotically Plausible Model Protocells

    • Authors : DasGupta, Saurja (2023)

  • Demonstrating RNA catalysis within prebiotically relevant models of primordial cells (protocells) remains a challenge in Origins of life research. Fatty acid vesicles encapsulating genomic and catalytic RNAs (ribozymes) are attractive models for protocells; however, RNA catalysis has largely been incompatible with fatty acid vesicles due to their instability in the presence of Mg2+ at concentrations required for ribozyme function. Here, we report a r...