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Journal Article

PROTECTIVE EFFECTS OF TRITERPENOID BETULIN ON TYPE 2 DIABETES MELLITUS IN RATS

Authors : Shlyahtun (2023)

According to current knowledge, type 2 diabetes mellitus (T2DM) is described as a complex metabolic condition that is characterized by long-term hyperglycemia followed by insulin resistance and relative lack of insulin production. It is emphasized that T2DM can cause severe complications, either of microvascular (retinopathy, nephropathy and neuropathy) or macrovascular (coronary heart disease, cardiomyopathy, arrhythmias and sudden death) origin. There has&#...

Journal Article

Structural properties of the HNF-1A transactivation domain

Authors : Kind, Laura (2023)

Hepatocyte nuclear factor 1α (HNF-1A) is a transcription factor with important gene regulatory roles in pancreatic β-cells. HNF1A gene variants are associated with a monogenic form of diabetes (HNF1A-MODY) or an increased risk for type 2 diabetes. While several pancreatic target genes of HNF-1A have been described, a lack of knowledge regarding the structure-function relationships in HNF-1A prohibits a detailed understanding of HNF-1A-mediated gene transcription, ...