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Browsing by Subject tropomyosin

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Journal article

Novel human cell expression method reveals the role and prevalence of posttranslational modification in non-muscle tropomyosins

Authors : Carman, Peter J. (2021)

Biochemical studies require large protein quantities, which are typically obtained using bacterial expression. However, the folding machinery of bacteria is inadequate for many mammalian proteins, which additionally undergo posttranslational modifications (PTMs) that bacteria, yeast, or insect cells cannot perform. Many proteins also require native N- and C-termini and cannot tolerate extra tag amino acids for function. Tropomyosin, a coiled coil ...

Journal article

Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms

Authors : Selvaraj, Muniyandi (2023)

The actin cytoskeleton is critical for cell migration, morphogenesis, endocytosis, organelle dynamics, and cytokinesis. To support diverse cellular processes, actin filaments form a variety of structures with specific architectures and dynamic properties. Key proteins specifying actin filaments are tropomyosins. Non-muscle cells express several functionally non-redundant tropomyosin isoforms, which differentially control the interactions of other proteins, including myosins ...