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Browsing by Subject trypanosome

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Journal article

A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of trypanosomes

Authors : Gerber, Markus (2023)

The AAA-ATPase Msp1 extracts mislocalized outer membrane proteins and thus contributes to mitochondrial proteostasis. Using pull down experiments we show that trypanosomal Msp1 localizes to both glycosomes and the mitochondrial outer membrane, where it forms a stable complex with four outer membrane proteins. The trypanosome-specific pATOM36 mediates complex assembly of a-helically anchored mitochondrial outer membrane proteins such as protein translocase sub...

Journal article

How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell

Authors : Nascimento, Janaina F. (2023)

ATP hydrolysis is required for the synthesis, transport and polymerization of monomers for 25 macromolecules as well as for the assembly of the latter into cellular structures. Other 26 cellular processes not directly related to synthesis of biomass, such as maintenance of 27 membrane potential and cellular shape, also require ATP. The unicellular flagellated 28 parasite Trypanosoma brucei has a complex digenetic life cycle. The primary...