Journal articleAuthors : Antico, Odetta (2021)
Autosomal recessive mutations in PINK1 and Parkin cause Parkinson’s
disease. How activation of PINK1 and Parkin leads to elimination of damaged
mitochondria by mitophagy is largely based on cell culture studies with few
molecular studies in neurons. Herein we have undertaken a global proteomic analysis of mitochondria from mouse neurons to identify ubiquitylated
substrates of endogenous Parkin activation. Comparative analysis with
... 
