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Journal article

A targeted isotope dilution mass spectrometry assay for Osteopontin quantification in plasma of metastatic breast cancer patients

Authors : Leslie, Andrew (2023)

Osteopontin (OPN) is a secreted glycophosphoprotein that derives its name from its high abundance in 33 bone and secretion by osteoblasts. It is also secreted by a number of immune cells and, therefore, is 34 present in human plasma at nanogram per millilitre levels where it affects cell adhesion and motility. 35 These properties implicate OPN as a promotor of tumor progression. Plasma OPN is primarily measured 36 by enz...

Journal article

Methylation in NDUFA13 gene promoter disrupts communication between collaborative transcription factors – potential mechanism for onset of breast cancer

Authors : Johanna, Hörberg (2023)

Selective DNA binding by transcription factors (TFs) is crucial for the correct regulation of DNA transcription. In healthy cells, promoters of active genes are hypomethylated. A single CpG methylation within a TF response element may change the binding preferences of the protein thus causing the dysregulation of transcription programs. Here we investigate a molecular mechanism driving the downregulation of NDUFA13 gene, due to hypermethylation, ...