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  • Journal article

  • Beyond the Active Site: The addition of a remote loop reveals a new complex biological function for chitinase enzymes

    • Authors : Kozome, Dan (2023)

  • Loops are small secondary structural elements that play a crucial role in the emergence of new 14 enzyme functions. However, our understanding of loop functions is mainly limited to the 15 catalytic loops. To understand the function of remote loops in enzymes, we studied Glycoside 16 hydrolase family 19 (GH19) chitinase - an essential enzyme family for pathogen degradation 17 in plants. By revealing the evolutionary history and loops appearance...