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  • OER000002558.pdf.jpg
  • Journal article

  • Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments

    • Authors : Oosterheert, Wout (2023)

  • The release of inorganic phosphate (Pi) from actin filaments constitutes a key step in their regulated turnover, which is fundamental to many cellular functions. However, the molecular mechanisms underlying Pi release from both the core and barbed end of actin filaments remain unclear. Here, we combine cryo-EM with molecular dynamics simulations and in vitro reconstitution to demonstrate how actin releases Pi through a ‘molecular backdoor’. ...
  • OER000002294.pdf.jpg
  • Journal Article

  • USING SMALL MOLECULES TO TURN AN RNA APTAMER INTO SENSORS FOR INORGANIC TARGETS WITHOUT IN VITRO SELECTION

    • Authors : aggarwal, Tushar (2023)

  • Aptamers are structured nucleic acid sequences that selectively bind a molecular target with high affinity. Aptamer sequences can be found in nature as gene regulation elements located in the untranslated regions of mRNAs,1 or discovered in the laboratory by in vitro selection (also known as SELEX: systematic evolution of ligands by exponential enrichment) from a random pool of nucleic acids.2,3 Some in vitroselected aptamers can bind ...