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Showing results 1 to 5 of 5
  • OER000002690-2.pdf.jpg
  • Journal article

  • Smart-design of universally decorated nano-particles for drug delivery applications driven by active transport

    • Authors : Halbi, Gal (2023)

  • Targeting the cell nucleus remains a challenge for drug delivery. Here we present a universal platform for smart design of nano-particles (NPs) decoration that allows recruitment of multiple dynein motors to drive their active motion towards the nucleus. The uniqueness of our approach is based on using: (i) a spacer polymer, commonly Biotin-Polyethylene-glycol-thiol (B-PEG-SH), whose grafting density and molecular weight can be tuned thereby allowing NP trans...
  • OER000002928.pdf.jpg
  • Journal article

  • Structural basis of polyamine transport by human ATP13A2 (PARK9)

    • Authors : Sim, Sue Im (2021)

  • Polyamines are small, organic polycations that are ubiquitous and essential to all forms of life. Currently, how polyamines are transported across membranes is not understood. Recent studies have suggested that ATP13A2 and its close homologs, collectively known as P5B-ATPases, are polyamine transporters at endo-/lysosomes. Loss-of-function mutations of ATP13A2 in humans cause hereditary early-onset Parkinson’s disease. To understand the polyamine ...
  • OER000001471.pdf.jpg
  • Ebooks (Sách điện tử)

  • Supply Chain - Recent Advances and New Perspectives in the Industry 4.0 Era

    • Authors : Bányai, Tamás (2022)

  • The Fourth Industrial Revolution has led to revolutionary changes in production and service processes. This book explains and examines the impact of Industry 4.0 technologies on supply chain solutions. It discusses the concept, design, and implementation of supply chain solutions using Industry 4.0 technologies. Chapters address such topics as supply webs, open innovation practices, lean manufacturing, the Internet of Things, green supply chain solutions, and much...
  • OER000001301-1.pdf.jpg
  • Book

  • The Multi-Agent Transport Simulation MATSim

    • Authors : W. Axhausen, Kay; Kai Nagel; Andreas Horni (2016)

  • The MATSim (Multi-Agent Transport Simulation) software project was started around 2006 with the goal of generating traffic and congestion patterns by following individual synthetic travelers through their daily or weekly activity programme. It has since then evolved from a collection of stand-alone C++ programs to an integrated Java-based framework which is publicly hosted, open-source available, automatically regression tested. It is currently used by about 40 gr...
  • OER000002626.pdf.jpg
  • Journal article

  • Ultrahigh-affinity transport proteins from ubiquitous marine bacteria reveal mechanisms and global patterns of nutrient uptake

    • Authors : Clifton, Ben E. (2023)

  • SAR11 bacteria are the most abundant members of the global ocean microbiome and have a broad impact on ocean ecosystems. To thrive in their competitive oligotrophic environments, these bacteria rely on solute-binding proteins (SBPs) that facilitate nutrient uptake through ABC transporters. Nonetheless, previous studies have been unable to access the molecular mechanisms and functions of these transporters because they rely heavily on homology-based p...