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Journal article

A CRISPR/Cas12a-assisted platform for identification and quantification of single CpG methylation sites

Authors : Dongen, J.E. van (2021)

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/associated nuclease (Cas) systems have repeatedly shown to have excellent performance in nucleotide sensing applications1– 8 5 9 . High specificity and selectivity of Cas effector proteins is determined by the CRISPR RNA’s (crRNA’s) interchangeable spacer sequence, as well as position and number of mismatches between target sequence and the crRNA sequence1 11 . Some diseases are characterized ...

Journal article

ChatGPT identifies gender disparities in scientific peer review

Authors : Verharen, Jeroen P. H. (2023)

The peer review process is a critical step in ensuring the quality of scientific research. However, its subjectivity has raised concerns. To investigate this issue, I examined over 500 publicly available peer review reports from 200 published neuroscience papers in 2022-2023. OpenAI’s generative artificial intelligence ChatGPT was used to analyze language use in these reports. It demonstrated superior performance compared to traditional...