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Showing results 1 to 3 of 3
  • OER000002990.pdf.jpg
  • Journal article

  • A common polymorphism that protects from cardiovascular disease increases fibronectin processing and secretion

    • Authors : Soubeyrand, Sébastien (2021)

  • Fibronectin (FN1) is an essential regulator of homodynamic processes and tissue remodeling which has been proposed to contribute to atherosclerosis. Moreover, recent large scale genome wide association studies have linked common genetic variants within the FN1 gene to coronary artery disease (CAD) risk. Genome-wide Association Studies (GWAS) have identified hundreds of common single nucleotide polymorphisms (SNPs) that associate with cardiovascular disease (CA...
  • OER000002709.pdf.jpg
  • Journal article

  • Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

    • Authors : Yadav, Ruchi (2023)

  • SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 34 pandemic. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved 35 by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essential 36 yet incompletely understood. We studied Mpro-mediated processing of the nsp7-10/11 37 polyprotein, whose mature products are cofactors of the viral replicase, identifying the&#...
  • OER000002367.pdf.jpg
  • Journal Article

  • Small Molecule Screen Identifies Non-Catalytic USP3 Chemical Handle

    • Authors : K. Mann, Mandeep (2023)

  • Zinc-finger ubiquitin binding domains (ZnF-UBDs) are non-catalytic domains mostly found in deubiquitylases (DUBs). They represent an underexplored opportunity for the development of deubiquitylase-targeting chimeras (DUBTACs) to pharmacologically induce the deubiquitination of target proteins. We have previously shown that ZnF-UBDs are ligandable domains. Here, a focused small molecule library screen against a panel of eleven ZnF-UBDs led to the identification of 5...