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dc.contributor.authorSignoretti, Christina-
dc.date.accessioned2023-11-13T09:13:08Z-
dc.date.available2023-11-13T09:13:08Z-
dc.date.issued2023-
dc.identifier.otherOER000002595vi
dc.identifier.urihttp://dlib.hust.edu.vn/handle/HUST/23459-
dc.description.abstractRecent advances have revealed the importance of epigenetic modifications to gene regulation and transcriptional activity. DNA methylation, a determinant of genetic imprinting and de novo silencing of genes genome-wide, is known to be controlled by DNA methyltransferases (DNMT) and demethylases (TET) under disease conditions. However, the mechanism(s)/factor(s) influencing the expression and activity of DNMTs and TETs, and thus DNA methylation, in healthy vascular tissue is incompletely understood. Based on our recent studies, we hypothesized that glucose-6-phosphate dehydrogenase (G6PD) is a modifier of DNMT and TET expression and activity and an enabler of gene expression.vi
dc.description.urihttps://www.biorxiv.org/content/10.1101/2023.03.06.531429v1.full.pdf+htmlvi
dc.formatPDFvi
dc.language.isoenvi
dc.publisherbioRxivvi
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Vietnam*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/vn/*
dc.subjectchuột biến thểvi
dc.subjectG6PDvi
dc.subjectmethyl hóavi
dc.subjectDNAvi
dc.subjectgenvi
dc.subject.lccQH506vi
dc.titleStudies in CRISPR-generated Mediterranean G6PD variant rats reveal G6PD orchestrates genome-wide DNA methylation and gene expression in vascular wallvi
dc.typeJournal articlevi
dc.description.noteCC BY 4.0vi
Appears in Collections:OER - Kỹ thuật hóa học; Công nghệ sinh học - Thực phẩm; Công nghệ môi trường

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