Investigating the antioxidant effects of Aloe vera: Possible role in regulating lipid profile and liver function in high fat and fructose diet (HFFD) fed mice

Abstract

Fat rich diets are believed to induce obesity and contributes to the development of diabetes and 23 cardiovascular disease while high fructose diet was reported to increase gut surface area and 24 enhance nutrient uptake resulting in weight gain. The study investigate the role of Aloe vera 25 supplementation on lipid profiles, oxidative stress as well as liver and hear histology in high fat 26 and fructose diet fed mice. Twenty mice were distributed into four groups (n=5). The groups 27 received regular diet, high fat and fructose died (HFFD), HFFD plus 10% Aloe vera (HFFD+AV1) 28 and HFFD plus 20% Aloe vera (HFFD+AV2) respectively for 10 weeks. The cholesterol level of 29 HFFD+AV treated mice were significantly lower compared to HFFD treated mice.