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dc.contributor.authorZhang, Qi-
dc.contributor.authorAguilera, Javier-
dc.date.accessioned2024-04-16T03:27:11Z-
dc.date.available2024-04-16T03:27:11Z-
dc.date.issued2020-
dc.identifier.otherOER000000744vi
dc.identifier.urihttp://dlib.hust.edu.vn/handle/HUST/24456-
dc.descriptionTài liệu này được phát hành theo giấy phép CC-BY-NC-ND 4.0vi
dc.description.abstractEsxA has long been recognized as an important virulence factor of Mycobacterium tuberculosis (Mtb) that plays an essential role in Mtb virulence. However, current data regarding to its role in Mtb virulence are controversial. Here, we have obtained evidence showing that the cytolytic activity of EsxA at neutral pH is due to contamination of ASB-14, a detergent used in EsxA preparation. Moreover, it is for the first time we have found that EsxA protein is endocytosed into lung epithelial cells and inserts into the host membranes within acidic subcellular compartments, implicating an important role of the acidic pH-dependent membrane permeabilizing activity of EsxA in Mtb virulence.vi
dc.description.urihttps://www.biorxiv.org/content/10.1101/2020.04.09.035238v1vi
dc.formatPDFvi
dc.language.isoenvi
dc.publisherBiochemical Journalvi
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Vietnam*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/vn/*
dc.subjectMycobacterium tuberculosisvi
dc.subjectEsxAvi
dc.subjectESAT-6vi
dc.subjectCytotoxicityvi
dc.subject.lccQD405vi
dc.titleMembrane Insertion of Mycobacterium tuberculosis EsxA in Cultured Lung Epithelial Cellsvi
dc.typeJournal articlevi
Appears in Collections:OER - Kỹ thuật hóa học; Công nghệ sinh học - Thực phẩm; Công nghệ môi trường

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