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dc.contributor.authorRoopnarine, Osha-
dc.contributor.authorThomas, David D.-
dc.date.accessioned2024-04-22T09:57:40Z-
dc.date.available2024-04-22T09:57:40Z-
dc.date.issued2020-
dc.identifier.otherOER000000222vi
dc.identifier.urihttp://dlib.hust.edu.vn/handle/HUST/24535-
dc.description.abstractthe effects of ten actin binding compounds on the interaction of cardiac myosin subfragment 1 (S1) with pyrene labeled F actin (PFA). These compounds, previously identified from a small-molecule high-throughput screen (HTS), perturb the microsecond structural dynamics of actin and the steady-state activity of actin-activated myosin ATPase. In the present study, we have further characterized their mechanisms of action by measuring their effects on PFA fluorescence, which is decreased specifically by the strong binding of myosin to actin, and is restored upon release of S1 by MgATP...vi
dc.description.urihttps://www.biorxiv.org/content/10.1101/2020.09.16.300517v1vi
dc.formatpdfvi
dc.language.isoenvi
dc.publisherJournal of Biological Chemistryvi
dc.rightsAttribution-NonCommercial 3.0 Vietnam*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/vn/*
dc.subjectActinvi
dc.subjectDrug actionvi
dc.subjectCompoundvi
dc.subjectMyosinvi
dc.subjectFluorescencevi
dc.subjectKineticsvi
dc.subjectHuỳnh quangvi
dc.subjectĐộng họcvi
dc.subject.lccRC685vi
dc.titleActin-binding compounds that affect the kinetics of the interaction of cardiac myosin with actinvi
dc.typeJournal articlevi
Appears in Collections:OER - Kỹ thuật hóa học; Công nghệ sinh học - Thực phẩm; Công nghệ môi trường

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