

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
 
 






 2015
T
 K- 2015
2

               







,
- 

T
 K- 2015
3


.

             

 các D

-



T
 K- 2015
4

 .................................................................................................. 1
 ............................................................................................ 3
 ........................................................................................................ 4
DANH MC BNG ...................................................................................... 10
LI M U ................................................................................................ 11
NG QUAN ......................................................................... 13
.......................... 13
 ............................................................................................. 13
  ............................................................... 13
 ............................................................................. 15
............................................................................. 17
 .............................................................................................. 22
1.2.Vi nang ...................................................................................................... 25
 ................................................................... 25
 ................................................................................ 25
 ................................................................................... 26
1.2. .......................................................................... 27
 .............................................................. 27
 .................................................................. 27
 ................................................................. 28
 ......................... 29
 ............................................................................. 29
 ............................................................................. 29
 ........................................................................ 30
 ................................................. 30
 .......................................... 31
T
 K- 2015
5
 ................................................................... 31
 ....................................................................................... 32
1.3.4.  ................................................................................... 32
 ..................................................................... 32
 ........................................................... 32
 ................................................... 33
-Vis. .................................................. 33
 .............................................. 35
 ............................................................ 35
 ............................................................. 37
1.5.1. Ibuprofen .............................................................................................. 37
1.5.2. Dung môi Ibuprofen .............................................................................. 37
 ................................. 37
 ................................................................................... 40
 ............ 41
 ................................................................................ 41
.............................................................................. 41
 ................................................................................ 42
2. .......................................................................... 43
 ...................................................... 43
 ....................................................................... 43
 ........................... 43
 ........................................................... 43
 ................................................................. 45
 ............................................................................ 46
 ............................................................ 46
 ................................................................. 47
T
 K- 2015
6

 .................................................................. 47
 ....................................................... 47
 ................................................................ 48
2.4.2.4.  ....................................... 49
 ................................................................................... 51
T QU NGHIÊN CU VÀ BÀN LUN ....................... 52
i ..................................... 52

 ................................................................................................ 52

 ................................................. 59

 ............... 59
-

 ................................................................................................................... 66
 ................................................................................... 69
 ............................................................................ 74
T
 K- 2015
7

 ...................................................................................... 12
 ............................................................................ 14
c ct vòng và chiu cao hàng vòng .......................................... 14
Hình 1.4: Vi dt kim  d ............................................. 16
i dt kim  ngang .......................... 17
 .................................................................... 18
 .................................................................. 18
 .............. 20
c MRS)................................... 21
            
interlock(c). ..................................................................................................... 22
 ............................................ 23
 .................................................. 24
 ............................................................ 24
 ...................................................................... 24
 .................................................... 25
Hình 1.16: Cu to vi nang và vi cu .............................................................. 26
Hình 1.17: Mt s hình nh vi nang ................................................................ 26
Hình 1.18 ............... 28
Hình 1.19 ................................................................. 28
Hình 1.20................................................... 29
Hình 1.21 ...................................................... 29
Hình 1.22 gii phóng hot cht ................................................... 31
Hình 1.23: Giy in cacbonless ........................................................................ 31
4 ...................................... 33
Hình 1.25......... Error! Bookmark not defined.
T
 K- 2015
8
Hình 1.26 nguyên lý thit b  ................................................ 34
7 Vis 3101 ................................................................. 35
8: Mô hình máy ph hp th u khic: ................. 35
9 nguyên lý máy ph hng ngoi hai chùm tia ...................... 36
Hình 1.30: Công thc hóa hc Ibuprofen ....................................................... 37
Hình 1.31: Quang ph hng ngoi ca (a) PCL-microspheres không ibuprofen
và (b) polymer PCL ......................................................................................... 38
Hình 1.32:Quang ph hng ngoi ca (a) PCL-microspheres vi ibuprofen và
(b) ibuprofen .................................................................................................... 39
a Ibuprofen.............................................................. 42
 ...................................................................................... 44
 hng ngoi Nicolet 6700 FTIR .................................... 44
Hình 2.4 : Máy quang ph t ngoi kh kin 4802 UV/VIS double beam
spectrophotometer ........................................................................................... 45
5: Ngâm mu vi nang khô trong dung môi heptane ............................ 46
Hình 2.6: Máy chp SEM(FEI QUANTA 200) .............................................. 47
7 ......................................................................... 47
8n trên mu mô phng ....................................... 49
9 ............................................... 49
10: Pha dung dich lng chun .................................................... 50
-VIS ...................................................................... 50
Hình 3.1: nh chp SEM v ........................................ 52
Hình 3.2 : nh  hng ngoi bng máy Nicolet 6700 FTIR ................. 52
 hng ngoi mu ngâm vi nang trong 3h (a), dic
 ........................................................................................................... 54
 hng ngoi mu ngâm vi nang trong 6h (a), dic
 ........................................................................................................... 55
T
 K- 2015
9
 hng ngoi mu ngâm vi nang trong 12h (a), dic
 ........................................................................................................... 56
 hng ngoi mu ngâm vi nang trong 24h (a), dic
 ........................................................................................................... 57
 i phóng
hot cht t vi nang ......................................................................................... 58
 IR mi cha vi nang v giãn 0% (a), din
 .............................................................................. 60
 IR mi cha vi nang v giãn 14.6 % (a),
di ....................................................................... 61
 IR mi cha vi nang v giãn 24.4 % (a),
di ....................................................................... 62
 IR mi cha vi nang v giãn 37.8 % (a),
di ....................................................................... 64
13 i phóng
hot cht t trên vi ch  c liu cha vi nang v  giãn
khác nhau ........................................................................................................ 65
T
 K- 2015
10

B thut ca máy Interlock ............................................ 41
Bng 2.2. Thông s công ngh ca vi ........................................................... 42
 .................. 45
Bng 2.4 : Ký hiu mu và t l giãn c  i khi qun trên mu mô
phng ............................................................................................................... 48
....... 58
....... 65
4- .......... 66
5-
 ................................................................................................. 67
Bng 3.6: N Ibuprofen trong các mu .................................................. 67
Bng 3.7: Khng hot cht Ibuprofen gii phóng trong các mu ........... 67
T
 K- 2015
11





             

c



 



 



 




.  
hút , 

soát 
T
 K- 2015
12

phóng  vi nang.
  

i phóng



bao gôm:
 
- 
- 
- 
- 
- 
 
Mục đích: 


Đối tượng nghiên cứu:  
Interlock.
Nội dung:
- 
- 
Phương pháp nghiên cứu:
- 
- 
- 
 