Browsing by Author Daffern, Nicolas

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  • OER000002330.pdf.jpg
  • Journal Article

  • Authors : Daffern, Nicolas (2023)

  • Transcriptional coactivators occupy an important niche in promoting gene transcription in eukaryotes. They lack the sequence-specific DNA-binding activity that characterizes transcriptional activators, but commonly serve two critical functions: (i) as molecular adaptors bridging promoter- and enhancer-bound activators with the transcription machinery and (ii) as agents that serve to overcome the repressive effects of chromatin [1, 2]. In the latter instance, ...