Journal ArticleAuthors : E strassler, sarah (2023)
The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the 9th nucleotide in
the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene
(TRMT10A) have been linked to neurological disorders such as microcephaly and intellectual disability, as
well as defects in glucose metabolism. Of the 26 tRNAs in yeast with guanosine at position 9, only 14 are
substrates ...