Browsing by Author Echeverria, Ignacia

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  • OER000000721.pdf.jpg
  • Journal article


  • Authors : Kwon, Yonghwa; Kaake, Robyn; Echeverria, Ignacia (2020)

  • The HIV-1 protein Nef suppresses multiple immune surveillance mechanisms to promote viral pathogenesis1. Individuals infected with HIV-1 encoding defective nef genes do not develop AIDS for decades2,3. A key target of Nef is the cellular receptor CD4. Although essential for viral entry into host cells, CD4 is problematic for the virus later in its replication cycle: CD4 disrupts processing of the viral glycoprotein, Env, inhibiting infectivity4; it inter...