Browsing by Author Ehrhardt, Jeffrey E

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  • OER000000783.pdf.jpg
  • Journal article


  • Authors : Ehrhardt, Jeffrey E; Weeks, Kevin M (-)

  • Methods for capturing the folding dynamics of functionally important RNAs, especially large RNAs, have relied primarily on global measurements of structure or on per-nucleotide chemical probing. These approaches infer, but do not directly measure, through-space tertiary interactions. Here we introduce trimethyloxonium (TMO) as a chemical probe for RNA. TMO enables time-resolved, single-molecule, through-space structure probing of RNA folding using a correlated chemical probing&#...