Browsing by Author Eletsky, Alexander

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  • OER000000914.pdf.jpg
  • Journal article


  • Authors : Kim, Hyun W; Eletsky, Alexander; Gonzalez, Karen J (2020)

  • Skp1 is an adapter that links F-box proteins to cullin-1 in the Skp1/cullin-1/F-box (SCF) protein family of E3 ubiquitin ligases that targets specific proteins for polyubiquitination and subsequent protein degradation. Skp1 from the amoebozoan Dictyostelium forms a stable homodimer in vitro with a Kd of 2.5 µM as determined by sedimentation velocity studies, yet is monomeric in crystal complexes with F-box proteins. To investigate the molecular basi...

  • OER000000914.pdf.jpg
  • Journal article


  • Authors : Kim, Hyun W; Eletsky, Alexander; Gonzalez, Karen J (2020)

  • Skp1 is an adapter that links F-box proteins to cullin-1 in the Skp1/cullin-1/F-box (SCF) protein family of E3 ubiquitin ligases that targets specific proteins for polyubiquitination and subsequent protein degradation. Skp1 from the amoebozoan Dictyostelium forms a stable homodimer in vitro with a Kd of 2.5 µM as determined by sedimentation velocity studies, yet is monomeric in crystal complexes with F-box proteins. To investigate the molecular basi...