Browsing by Author Gao, Shuai

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  • OER000000862.pdf.jpg
  • Journal article

  • Authors : Ren, Zhenning; Gao, Shuai; Shen, Jiemin (2020)

  • Ferroportin is the only cellular iron exporter in human and essential for iron homoeostasis. Mutations in ferroportin are associated with hemochromatosis or ferroportin diseases characterized by a paradoxical combination of anemia and abnormal accumulation of iron in cells. Ferroportin is also the target of hepcidin, which is a hormone that downregulates ferroportin activity. However, due to a lack of three-dimensional structures, the mechanism of iron transport&#...