Browsing by Author J, Lauer

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  • OER000004017.pdf.jpg
  • Journal article

  • Authors : A, Cezanne; J, Lauer; A, Solomatina (2019)

  • Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effector binding, generating a positive feedback of GTPase activation and membrane recruitment. Here, we reconstituted the patterning of the small GTPase Rab5 and its GEF/effector complex Rabex5/Rabaptin5 on supported lipid bilaye...