Browsing by Author Jaiswal, Rahul

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  • Periodicals (Báo – Tạp chí)

  • Authors : Santosh, Vishaka; Musayev, Faik; Jaiswal, Rahul (2020)

  • The adeno-associated virus (AAV) Rep proteins use a unique AAA+ domain to catalyze DNA replication, transcription regulation, and genome packaging. Also, they mediate site-specific integration during a latent phase. To understand the mechanisms underlying AAV Rep function, we investigated the cryo-EM and X-ray structures of Rep68-ssDNA complexes. Surprisingly, Rep68 generates hybrid ring structures where the Origin-Binding-Domain (OBD) forms octameric rings while the helicase&#x...