Browsing by Author Nagarajan, Karthi

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  • OER000000729.pdf.jpg
  • Journal article

  • Authors : Simon, Kailene S; Nagarajan, Karthi; Mechin, Ingrid (2020)

  • Cystic fibrosis (CF) results from mutations within the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), a transmembrane chloride channel found on the apical surface of epithelial cells. The most common CF-causing mutation results in a deletion of phenylalanine 508 (ΔF508-CFTR), a residue normally found within the NBD1 domain. Loss of F508 causes NBD1 to be less thermodynamically stable and prevents proper tertiary folding of CFTR....