Browsing by Author Naqvi, Mohsin M

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  • OER000000749.pdf.jpg
  • Journal article

  • Authors : Mullally, Grace; Aelst, Kara van; Naqvi, Mohsin M (2020)

  • A key aim in exploiting CRISPR-Cas is the engineering of gRNA to introduce additional functionalities, ranging from small nucleotide changes that increase efficiency of on-target binding to the inclusion of large functional RNA aptamers and ribonucleoproteins (RNPs. Interactions between gRNA and Cas9 are crucial for RNP complex assembly but several distinct regions of the gRNA are amenable to modification. Using a library of modified gRNAs, we used in&#x...