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Browsing by Author Obi, Juliet O

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  • OER000000675.pdf.jpg
  • Journal article

  • The BRPF1 bromodomain is a molecular reader of di-acetyllysine

    • Authors : Obi, Juliet O; Lubula, Mulu Y; Cornilescu, Gabriel (2020)

  • Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ (monocytic leukemic zinc-finger protein) HAT (histone acetyltransferase) complex, which is associated with chromosomal translocations known to contribute to the development of acute myeloid leukemia (AML). BRPF1&#...