Browsing by Author Raasakka, Arne

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  • OER000000213.pdf.jpg
  • Journal article

  • Authors : Mahootchi, Elaheh; Raasakka, Arne; Luan, Weisha (2020)

  • the crystal structure of mouse CSAD and compared it to other PLP-dependent decarboxylases in order to identify determinants of substrate specificity and catalytic activity. Recognition of the substrate involves distinct side chains forming the substrate-binding cavity. In addition, the backbone conformation of a buried active-site loop appears to be a critical determinant for substrate side chain binding in PLPdependent decarboxylases. phe94 was predicted to affect...