Browsing by Author Raducanu, Vlad-Stefan

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  • OER000004027.pdf.jpg
  • Journal article

  • Authors : Lancey, Claudia; Tehseen, Muhammad; Raducanu, Vlad-Stefan (2019)

  • In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. We present the high-resolution cryo-EM structure of the human processive Pol δ-DNA-PCNA complex in the absence and presence of FEN1. Pol δ is anchored to one of the three PCNA monomers through the C-terminal domain of ...