Browsing by Author Saei, Amir Ata

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  • OER000000925.pdf.jpg
  • Journal article

  • Authors : Saei, Amir Ata; Beusch, Christian M; Sabatier, Pierre; Wells, Juan Astorga (2020)

  • Despite the immense importance of enzyme-substrate reactions, there is a lack of generic and unbiased tools for identifying and prioritizing substrate proteins which are modulated in the structural and functional levels through modification. Here we describe a high-throughput unbiased proteomic method called System-wide Identification and prioritization of Enzyme Substrates by Thermal Analysis (SIESTA). The approach assumes that enzymatic post-translational modification of substrate&...