Browsing by Author Sahoo, Manisha Priyadarsini

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  • OER000002343.pdf.jpg
  • Journal Article

  • Authors : Sahoo, Manisha Priyadarsini (2023)

  • Proteasomes are multi-subunit, multi-catalytic protein complexes present in eukaryotic cells that degrade misfolded, damaged, or unstructured proteins. In this study, we used an activity-guided proteomic methodology based on a fluorogenic peptide substrate to characterize the composition of proteasome complexes in WT yeast, and the changes these complexes undergo upon the deletion of Pre9 (Δα3) or of Sem1 (ΔSem1). A comparison of whole-cell proteomi...