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Browsing by Author Sahu, Abhishek

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  • OER000002354.pdf.jpg
  • Journal Article

  • Drug repurposing approach for potential Pfmrk inhibitors as antimalarial agents: an In-silico analysis

    • Authors : Sahu, Abhishek (2023)

  • Malaria is a major global health issue due to the emergence of resistance to most of the available antimalarial drugs. There is an urgent need to discover new antimalarials to tackle the resistance issue. A CDK- like protein, Pfmrk from Plasmodium falciparum, plays a crucial role in regulating cell proliferation and shares 36.28% homology with humans CDK (hCDK7). Pfmrk complex with Pfcyc-1 and stimulates kinase activity. Also, Pfcyc-1 from P.&#...