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  • OER000002930.pdf.jpg
  • Journal article

  • Cooperativity of catalytic and lectin-like domain of T. congolense trans-sialidase modulates its catalytic activity

    • Authors : Waespy, Mario (2021)

  • Trans-sialidases (TS) represent a multi-gene family of unusual enzymes, which catalyse the transfer of terminal sialic acids from sialoglycoconjugates to terminal galactose or N 30 acetylgalactosamine residues of oligosaccharides without the requirement of CMP-Neu5Ac, the activated Sia used by typical sialyltransferases. Most work on trypanosomal TS has been done on enzymatic activities of TS from T. cruzi (causing Chagas disease in Latin America), s...