Browsing by Author Wakabayashi, Hironao

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  • OER000000732.pdf.jpg
  • Journal article

  • Authors : Wakabayashi, Hironao; Warnasooriya, Chandani; Ermolenko, Dmitri N (2020)

  • By forming basepairing interactions with the 3’ end of 16S rRNA, mRNA Shine-Dalgarno (SD) sequences positioned upstream of Open Reading Frames (ORFs) facilitate translation initiation. During the elongation phase of protein synthesis, intragenic SD-like sequences stimulate ribosome frameshifting and may also slow down ribosome movement along mRNA. Here, we show that the length of the spacer between the SD sequence and P-site codon strongly affects the rate&#x...