Browsing by Author Walvekar, Adhish S

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  • OER000000692.pdf.jpg
  • Journal article

  • Authors : Walvekar, Adhish S; Kadamur, Ganesh; Sreedharan, Sreesa (2020)

  • Methionine, through S-adenosylmethionine, activates multifaceted growth programs where ribosome biogenesis, carbon metabolism, amino acid and nucleotide biosynthesis are induced. This growth program requires activity of the Gcn4 transcription factor (called ATF4 in mammals), which enables metabolic precursor supply essential for anabolism. Here, we discover how the Gcn4 protein is induced by methionine, despite conditions of high translation and anabolism. This induction mechanism&#x...