Browsing by Author Zarcone, Lucrezia

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  • OER000000754.pdf.jpg
  • Journal article

  • Authors : Grieve, Adam G; Yeh, Yi-Chun; Zarcone, Lucrezia (2020)

  • Calcium influx through plasma membrane calcium release-activated calcium (CRAC) channels, which are formed of hexamers of Orai1, is a potent trigger for many important biological processes, most notably in T cell mediated immunity. Through a bioinformatics-led cell biological screen, we have identified Orai1 as a substrate for the rhomboid intramembrane protease, RHBDL2. We show that RHBDL2 prevents stochastic signalling in unstimulated cells through conformational sur...