Browsing by Author Zargar, Amin

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  • OER000000682.pdf.jpg
  • Journal article

  • Authors : Zargar, Amin; Lal, Ravi; Valencia, Luis (2020)

  • Polyketide synthase (PKS) engineering is an attractive method to generate new molecules such as commodity, fine and specialty chemicals. A significant challenge in PKS design is engineering a partially reductive module to produce a saturated β-carbon through a reductive loop exchange. In this work, we sought to establish that chemoinformatics, a field traditionally used in drug discovery, could provide a viable strategy to reductive loop exchanges. We fi...