Browsing by Author Zarrow, Jonah E

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  • OER000000831.pdf.jpg
  • Journal article

  • Authors : Aggarwal, Geetika; Zarrow, Jonah E; Mashhadi, Zahra (-)

  • N-acyl-phosphatidylethanolamine phospholipase D (NAPE-PLD) (EC catalyzes the final step in the biosynthesis of N-acyl-ethanolamides (NAEs). Reduced NAPE-PLD expression and activity may contribute to obesity and inflammation, but a major obstacle to elucidating the role of NAPE-PLD and NAE biosynthesis in various physiological processes has been the lack of effective NAPE-PLD inhibitors. The endogenous bile acid lithocholic acid (LCA) inhibits NAPE-PLD activity (IC50...