Browsing by Author Zhang, Bingjie

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  • Journal article


  • Authors : Zhang, Bingjie; Zhao, Simeng; Yang, Dehua (2020)

  • Subtype selectivity and functional bias are vital in current drug discovery for G protein-coupled receptors (GPCRs) as selective and biased ligands are expected to yield drug leads with optimal on-target benefits and minimal side-effects. However, structure-based design and medicinal chemistry exploration remain challenging in part because of highly conserved binding pockets within subfamilies. Herein, we present an affinity mass spectrometry approach for screening herbal&#...